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Assessment of Nutritional Status in chest and Pelvic cancer Patients undergoing Radiation Therapy

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KMID : 1190719990040010207
¼ÒÇâ¼÷ ( So Hyang-Sook ) - ¼Ò¼ÓÈ®ÀÎÁß

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ÀÌÀº¼÷ (  ) - ¼Ò¼ÓÈ®ÀÎÁß

Abstract

º» ¿¬±¸´Â Èä°û ¶Ç´Â °ñ¹ÝºÎÀ§¿¡ ¹æ»ç¼±Á¶»ç¸¦ ¹ÞÀº ¾ÏȯÀÚ 48¸íÀ» ´ë»óÀ¸·Î ¹æ»ç¼± Ä¡·á Á¾·á½Ã±â¿¡ ¿µ¾ç»óÅ Áï ½Åü°èÃø(üÁß, »ïµÎ¹Ú±Ù ÇÇÇÏÁö¹æµÎ²², »ó¹ÚµÑ·¹, »ó¹Ú±ÙÀ°µÑ·¹)°ú »ýÈ­ÇÐÀû ÃøÁ¤(¾ËºÎ¹Î, Ç÷»ö¼ÒÄ¡, ÃÑÀÓÆı¸¼ö) ¹× ¾Ç·ÂÀ» ÃøÁ¤ÇÏ¿´´Ù. ¼öÁýµÈ ÀÚ·á´Â SAS¸¦ »ç¿ëÇÏ¿©¼­ Èä°û°ú °ñ¹ÝºÎÀ§º°·Î ¾Ï ȯÀÚÀÇ ¿µ¾ç»óÅ°¡ Â÷ÀÌ°¡ ³ª´Â Áö¿Í ¿µ¾ç»óÅ º¯Àε鰣ÀÇ °ü°è¸¦ ÆľÇÇÏ¿´´Ù.
ºÐ¼®µÈ °á°ú´Â ´ÙÀ½°ú °°´Ù.
1. ´ë»óÀÚ 85%°¡ 50¡­60´ë·Î, Èä°ûºÎÀ§ ¾ÏÀº 26¸íÀÌ ³²ÀÚ(1¸í¸¸ÀÌ ¿©ÀÚ)¿´°í ÀüüÀÇ 56%¸¦, °ñ¹ÝºÎÀ§ ¾ÏÀº ÀüüÀÇ 44%¸¦ Â÷ÁöÇÏ¿´°í ±×Áß 71%°¡ ¿©¼ºÀ̾ú´Ù. ¾Ï Ä¡·áÀ¯ÇüÀ» º¸¸é ±ÙÄ¡Àû ¹æ»ç¼±Á¶»ç¸¸À» ¹ÞÀº °æ¿ì´Â 58%¸¦, ¼ö¼ú ÈÄ º¸Á¶Àû ¹æ»ç¼±Á¶»ç¸¦ ¹ÞÀº °æ¿ì°¡ 42% À̾ú´Ù. ¹æ»ç¼± Á¶»ç·®Àº 6,000rad ¹Ì¸¸ ±ºÀÌ 54%¸¦, 6,000rad ÀÌ»ó ±ºÀÌ 46%¸¦ Â÷ÁöÇÏ¿´´Ù.
2. ³²ÀÚÀÇ TSF´Â 8.75¡¾4.10§® ÀÌ°í ¿©ÀÚ´Â 14.97¡¾5.44§® À̾ú±â¿¡ ³²³à ¸ðµÎ Á¤»óÀÎÀÇ 5th¡­50th%¿¡ ÇØ´çµÇ¾ú´Ù. »ïµÎ¹Ú±Ù ÇÇÇÏÁö¹æµÎ²²¿Í ÃÑÀÓÆı¸¼ö¸¸ÀÌ Ç¥ÁØÄ¡¿¡ Å©°Ô ¸ø ¹ÌÃÆÀ¸¸ç ƯÈ÷ Ç÷Áß ¾ËºÎ¹ÎÄ¡´Â Á¤»ó¼öÁØ¿¡ ÇØ´çµÇ¾úÀ¸³ª Çì¸ð±Û·Îºó Ä¡´Â Á¤»ó¼öÁØ¿¡ ¾à°£ ¸ø ¹ÌÃÆ´Ù. ÃÑÀÓÆı¸¼ö´Â Èä°ûºÎÀ§ÀÇ °æ¿ì´Â 900/§§ ÀÌÇÏÀÇ ÁߵÀÇ ¿µ¾ç°áÇÌÀ» ±×¸®°í °ñ¹ÝºÎÀ§´Â 800/§§ÀÌÇÏÀÇ ÁßÁõÀÇ ¿µ¾ç°áÇÌ»óŸ¦ º¸¿´´Ù.
3. Èä°û°ú °ñ¹ÝºÎÀ§ ¹æ»ç¼± Ä¡·á¸¦ ¹Þ´Â ¾ÏȯÀÚÀÇ ¿µ¾ç»óÅÂÀÇ Â÷À̸¦ °ËÁõÇÑ °á°ú, »ïµÎ¹Ú±Ù ÇÇÇÏÁö¹æµÎ²²(TSF), »ó¿ÏµÑ·¹(MAC), ¾Ç·Â, Çì¸ð±Û·Îºó Ä¡ ±×¸®°í Ç÷ Áß ¾ËºÎ¹Î Ä¡´Â À¯ÀÇÇÑ Â÷À̸¦ º¸¿©¼­, TSF¿Í MAC ¹× Ç÷ Áß ¾ËºÎ¹Î Ä¡´Â Èä°ûºÎÀ§¿¡ ºñÇÏ¿© °ñ¹ÝºÎÀ§ ¾ÏȯÀÚ°¡ ³ôÀº ¼öÄ¡¸¦ º¸¿´°í(t=4.26, p=.000 ; t=3.33, p=.002, t=2.42, p=.020) ¾Ç·Â°ú Çì¸ð±Û·Îºó Ä¡´Â °ñ¹ÝºÎÀ§¿¡ ºñÇÏ¿© Èä°ûºÎÀ§ ¾ÏȯÀÚ°¡ ³ôÀº ¼öÄ¡¸¦ º¸¿´´Ù(t=3.73, p=.000 ; t=2.39, p=.021).
üÁß, »ó¿ÏµÑ·¹ ¹× ÃÑÀÓÆı¸¼ö´Â Èä°û°ú °ñ¹ÝºÎÀ§ ¾ÏȯÀÚ°£ÀÇ Â÷ÀÌ°¡ ¾ø¾ú´Ù.
4. ¹æ»ç¼±Ä¡·á Á¾·á½Ã±âÀÇ ¿µ¾ç»óÅ º¯Àε鰣ÀÇ »ó°ü°ü°è¸¦ ºÐ¼®ÇÑ °á°ú, üÁßÀº »ó¿ÏµÑ·¹, »ó¿Ï±ÙµÑ·¹ ¹× Ç÷»ö¼Ò¿Í ³ôÀº Á¤»ó°üÀÌ ÀÖ¾ú°í(r=.667, p=.0001 ; r=.677, p=.0001 ; r=.529, p=.0001) ÃÑÀÓÆı¸¼Ò¿Íµµ ¾àÇÑ Á¤»ó°üÀÌ ÀÖ¾ú´Ù(r=.353, p=.014). ÇÇÇÏÁö¹æµÎ²²´Â »ó¿ÏµÑ·¹¿Í Á¤»ó°ü(r=.551, p=.0001) Ç÷»ö¼Ò ¹× ¾Ç·Â°ú´Â ¿ª»ó°üÀÌ ÀÖ¾ú´Ù(r=-.312, p=.030 ; r=-.650, p=.0001). »ó¿ÏµÑ·¹´Â »ó¿Ï±ÙµÑ·¹¿Í ³ôÀº Á¤»ó°üÀÌ ÀÖ¾ú´Ù(r=.827, p=.0001). Ç÷»ö¼Ò´Â üÁß, »ó¿Ï±ÙµÑ·¹, ÃÑÀÓÆı¸¼ö ¹× ¾Ç·Â°ú Á¤»ó°üÀ» º¸¿´´Ù(r=.529, p=.0001 ; r=.388, p=.006 ; r=.413, p=.003 ; r=.341, p=.021).
º» ¿¬±¸°á°ú¸¦ Åä´ë·Î ´ÙÀ½°ú °°Àº Á¦¾ðÀ» ÇÑ´Ù. ¾ÕÀ¸·ÎÀÇ ¿¬±¸´Â ¿µ¾ç»óÅÂ¿Í ¸é¿ª±â±ÙÀÌ À§ÇèÇÑ Áý´ÜÀ» Áß½ÉÀ¸·Î ¾ÏȯÀÚÀÇ ¿µ¾ç°á¼ÕÀ» ¿¹¹æÇϱâ À§ÇÏ¿© ÀüÇâÀûÀÎ ¿µ¾ç»óÅ Æò°¡¿Í ¿µ¾çÁö¿øÀ» ½Ç½ÃÇÔÀ¸·Î½á ±× È¿°ú¸¦ ÃøÁ¤ÇÏ´Â ½ÇÇ迬±¸°¡ ÇÊ¿äÇÏ´Ù°í º»´Ù.

This study was conducted to assess nutritional status of 48 cancer patients who completed executive cycles of radiation therapy on chest or pelvic area. The data were gathered May 1 to December 30, 1996 through the anthropometric and biochemical measures such as weight, triceps skinfold thickness, mid-arm circumference, mid-arm muscle circumference, hand grip, serum albumin, hemoglobin, & total lymphocyte count. The data were analyzed boy percentage, Mean¡¾SD, chi-square test, t-test, Pearson¡¯s correlation & tow-away ANOVA using SAS program.
The results were summarized as follows :
1. Eighty five percentage of the subjects were the fifties to sixties. Cancers of the chest area occur in all men(excluding one), 56% among all subjects. The others occur in pelvic area and 71% among them were women. The number of patients who received curative radiation therapy only were 58% and the others had operation and adjuvant radiotherapy.
Patients who irradiated less than 6,000 rads were 54% and the others had radiation dose above 6,000 rads.
2. TSF was 8.75¡¾4.10§® in men and 14.97¡¾5.44§® in women. These come under 5th¡­50th % among normal persons. Total lymphocyte count of chest cases was less than 900/§§, i.e., moderate depletion and that of pelvic cases was less than 800/§§, i.e., severe depletion.
3. There were significant differences of TSF, MAC, level of hemoglobin, level of albumin, & hand grip by cancer areas. But there were no significant differences of the body weight, MAMC, & TLC by cancer areas.
TSF, MAC, & levels of serum albumin on pelvic cases were higher than those on chest cases(t=4.26, p=.000 ; t=3.33, p=.002, t=2.42, p=.020). Hand grip and level of hemoglobin on pelvic cases were lower than those on chest cases(t=3.73, p=.000 ; t=2.39, p=.021).
4. In completing radiation therapy, body weight was positively correlated with MAC, MAMC, level of hemoglobin, & TLC(r=.667, p=.0001 ; r=.677, p=.0001 ; r=.529, p=.0001 ; r=.353, p=.014). TSF was positively correlated with MAC(r=.551, p=.0001), negatively with level of hemoglobin & hand grip(r=-.312, p=.030 ; r=-.650, p=.0001). MAC was positively correlated with MAMC(r=.827, p=.0001). Level of homoglobin was positively correlated with body weight, MAC, MAMC, TLC & hand grip(r=.529, p=.0001 ; r=.388, p=.006 ; r=.413, p=.003 ; r=.341, p=.021).
KeyWords

chest and pelvic cancer, radiotherapy, nutritional assessment
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